Cold hands and feet during fever are usually a sign of rising body temperature. Fever refers to an increase in body temperature, and there are typically three periods of elevated body temperature, namely the period of rising body temperature, the period of plateauing body temperature, and the period of falling body temperature. There are two physiological responses during the period of rising body temperature, which are increased heat production and decreased heat dissipation. Cold hands and feet indicate a decrease in heat dissipation because the surrounding capillaries are constricted, which indicates a decrease in heat dissipation. Therefore, after the temperature is measured at this time, it is important to look at the specific value and then retest it, usually the temperature measured at this time is not the highest. If the temperature reaches a level that requires antipyretic drugs, it is necessary to apply antipyretic drugs; if not, it is likely to be necessary to take antipyretic drugs when it is close to this value.