Numbness of the hands and feet can be caused by many reasons, as follows: First, neurological diseases, sudden onset of persistent numbness of one side of the hands and feet, can be seen in the middle-aged and elderly with hypertension, coronary heart disease, diabetes mellitus, suggesting that the acute cerebrovascular disease, should be consulted as soon as possible in the neurological emergency room. Second, endocrine diseases, diabetic patients with long-term higher-than-normal blood glucose, will affect the peripheral nerves, resulting in patients with diabetic peripheral neuropathy, involved in the endings of the hands and feet, the feeling of numbness, then line electromyography can be a clear diagnosis. Third, local strain disease, due to excessive stretching or strain injury, resulting in tendon injury, and compression of nerves, causing blood circulation disorders, numbness can also occur. Numbness can be relieved by recuperation and local physical therapy, or oral vitamin B and other nutritive drugs can be restored.