Of all the bones and joints in the human body, the complexity and importance of the wrist joint is far out of proportion to the degree to which its pathogenesis has been emphasized, recognized, and addressed. Perhaps because it is too complex, people stay away from it, or perhaps because its treatment is unsatisfactory in the near and distant future, people are disappointed with it. As a result, carpal tunnel pain has become an unbearable lightness in bone and joint pain. However, as people’s understanding of the wrist joint becomes more and more in-depth, and people’s demand for quality of life becomes higher and higher, carpal tunnel pain is receiving more and more attention and concern. There are more and more methods and means for the research and diagnosis and treatment of carpal joint diseases. Many diseases have been more and more clearly recognized, and many methods are more and more mature. The wrist joint consists of the ulna, the distal radius, eight carpal bones and five metacarpal bases, including the inferior ulnar-radial joint, the radial-wrist joint, the intercarpal joint and the carpometacarpal joint. More than two dozen ligaments and the triangular cartilage complex (TFCC) connect these bones and joints into a joint complex that transmits, carries, and supports from the forearm to the hand. Its function is synergized by the radial, median and ulnar nerves. Its anatomy is delicate and its synergy is fine. Any bone or ligament injury or even contracture of the skin scar can cause pain in the wrist joint. The pain caused by wrist disorders will make the patient unable to sleep at night, lose the rhythm of life, unable to move his/her hands such as opening and pushing doors, and unable to work with a weak grip. The impact on life and work is enormous. The causes of wrist pain are systemic, localized, congenital and traumatic. Systemic diseases leading to wrist joint pain is the most popular wind-like off and pain in the wind wrist joint involvement. Particularly, familial hereditary rheumatoid arthritis can involve the carpal joint at an early stage and cause joint destruction and deformity. Early medical treatment should be accompanied by brace and rehabilitation physiotherapy for the carpal joint. The earlier the intervention, the later the deformity occurs and the longer the life of the wrist joint. In the case of obvious deformity and pain that affects the quality of life and work, surgical correction of the deformity or even fusion of the limited or total carpal joint should be considered. Some pregnant women also experience vague pain in the wrist and numbness in the fingers during the middle and late stages of pregnancy. This may be due to increased fluid metabolic load in the body, increased hormone levels, and median nerve entrapment due to edema and thickening of the transverse carpal ligament. Conservative treatment, such as rehabilitation and physiotherapy with immobilization in a brace, can provide relief, and the majority of symptoms disappear after delivery, while very few require surgical intervention, and other localized diseases of the wrist need to be ruled out. Localized causes are more complex. Any injury that causes bone, cartilage, ligament, or TFCC in the wrist will cause pain in the wrist. Trauma-induced fractures of the constituent bones of the wrist, especially those involving articular surface cartilage, cause osteoarthritis, and injuries to important ligaments such as the navicular ligament, radial navicular ligament, and radial navicular head ligament can cause joint instability, uncoordinated wrist motion, and abnormal motion and distribution of forces can cause arthritis in one or more joints, which can cause or exacerbate pain.TFCC is another common wrist pain The cause. Due to its anatomical peculiarities, uneven distribution of blood flow and complexity of mechanical transmission, sometimes a small trauma can cause pain on the ulnar side of the wrist, which will be aggravated by unimmobilized and appropriate treatment, and the pain will further worsen, even requiring surgical treatment. Another cause of wrist pain of great concern is aseptic necrosis of the carpal bones. For example, aseptic necrosis of the lunate bone and aseptic necrosis of the navicular bone. Necrosis of these carpal constituent bones causes localized collapse, biomechanical imbalance of the carpal joint, and arthritis of adjacent osteoarthritic joints, resulting in pain and loss of function of the carpal joint. Therefore, when there is pain in the wrist joint without any reason, or when some occupational workers, such as those who have been holding a wind rotor for a long time, have sustained impact between the bones of the wrist joint, resulting in edema of the medullary cavity and increased pressure; some patients with positive or negative ulnar variations, also due to the abnormal weight-bearing impact on the ulna, and some patients with congenital anomalies of the carpal joint such as congenital navicular-lunar fusion, congenital ligamentous laxity of the carpal joint, and excessive laxity of the capsule, patients should be referred to the clinic for the first time. In addition to conventional X-ray, an MRI of the wrist joint is very necessary to determine not only the soft tissue status of the wrist joint, but also the blood supply of the constituent bones of the wrist joint to a certain extent. Early diagnosis and treatment of this type of wrist pain will result in a significantly better outcome than when abnormalities are apparent on the imaging data. Trauma-induced wrist pain is by far the leading cause of wrist pain in our country. Due to insufficient knowledge of the carpal joint and underestimation of the condition, the early stage of trauma may only focus on the carpal constituent bones, such as focusing on the treatment of distal radius fracture and neglecting the diagnosis and treatment of the navicular ligament, and the clinical reconstruction of navicular ligament injuries, despite the many methods, but the results of the near and distant future are not as good as expected. Further, dislocation of the lunate and transnavicular fracture, periprosthetic dislocation of the lunate, early repetitive repositioning and inappropriate incisional repositioning as well as missed early repositioning may cause aseptic necrosis of the lunate; and missed navicular fracture may cause malunion, nonunion, and localized necrosis of the navicular bone. All of these may cause localized osteoarthritis and cause wrist pain. Another important cause of wrist pain is the hemorrhage and edema of the contents of carpal tunnel and carpal ulnar tunnel caused by wrist trauma and surgery, causing compression of the median nerve and ulnar nerve, at this time, there are not only wrist symptoms, but also numbness in the corresponding innervation area of the hand and atrophy of intrinsic muscles of the hand. Early decompression and proper immobilization will have unexpected results. A very important aspect in the treatment of carpal tunnel pain is the assessment of pain and the patient’s functional requirements of the wrist. In patients with severe localized symptoms and a short-term requirement for carpal use, local closure therapy such as Depo-Prostone can provide significant relief, but it should be noted that hormones can exacerbate damage to osteoarticular cartilage. For surgical treatment, whether it is reconstruction or immobilization, adequate communication with the patient is needed. Wrist pain is an affliction of great clinical concern. We can no longer trivialize its existence. It is imperative to pay attention to it, study it, and understand it. Wrist pain is no longer a lightweight in bone and joint disorders.