Clinical anti-O increase, mainly depends on whether the patient has relevant clinical symptoms, if the patient does not have clinical symptoms, all indicators are normal, can not be treated. Anti-O is a reaction of the organism infected with A-type hemolytic streptococcus, after infection with this bacterium, there will be an increase in anti-O, which may induce myocarditis or reactive arthritis, acute glomerulonephritis after infection, but after infection is not certain to develop these diseases, so clinically it is necessary to decide whether to treat according to the patient has no relevant symptoms and examination abnormalities. If the patient has symptoms of kidney and acute glomerulonephritis, such as oliguria, proteinuria, kidney damage and increased anti-O, considering the possibility of acute glomerulonephritis, clinically, we have to apply drugs for the treatment of hemolytic streptococcus to the patient, and we can consider the application of penicillin for treatment. However, if the patient does not have any symptoms, just after the recent infection, after the emergence of type A hemolytic streptococcus anti-O increase, no treatment is generally not a big problem.