Mesalazine enteric-coated tablets are still not good even after half a year of taking them may be caused by the development of drug resistance, the use of separate medication, incorrect use of medication, and so on. 1. Resistance: If you take medication for too long, you may develop resistance to mesalazine enteric-coated tablets, which is not effective when you take medication, and you usually need to take other medications, such as sulfasalazine, oxalazine, and so on. 2. separate medication: for many diseases need to be treated with a combination of drugs, if colitis is serious, especially when there is a serious bacterial infection, the use of mesalazine enteric-coated tablets alone is often ineffective, you need to work with antibiotics such as levofloxacin and other antibiotics, and take hormonal drugs such as prednisolone, if necessary. 3. Incorrect use of drugs: may be caused by the wrong medicine, such as intestinal polyps using medication is not effective, the need to take surgical treatment. Mesalazine enteric-coated tablets with six months of medication is not good, you should stop the drug in a timely manner to consult a doctor to find out the reasons for the timely standardization of diagnosis and treatment under the guidance of a doctor.