The common causes of blisters on the buttocks include eczema, genital herpes, etc. Other causes such as diaper dermatitis, hand-foot-mouth disease, herpes zoster, chickenpox, etc. can also cause blisters on the buttocks. 1. eczema: eczema is an inflammatory skin reaction caused by a variety of complex factors. Patients with eczema can have papules or small blisters on various parts of the body, with a flushed base, and usually accompanied by intense itching. It is generally difficult to cure eczema, usually using glucocorticoids, antihistamines for anti-inflammatory, anti-allergy treatment; 2, genital herpes: genital herpes is generally caused by the herpes virus, can be transmitted through sexual contact, often in the perineum, labia, penis, scrotum, etc., appear clustered distribution of blisters, homosexuals can be found in the anus, buttocks, generally can be applied acyclovir ointment, oral acyclovir tablets or vaxilovir 3, other: diaper dermatitis, hand-foot-mouth disease, herpes zoster, chickenpox, etc. can also cause blisters on the buttocks, which need to be identified according to the patient’s own signs and professional examination to clarify the cause and then perform targeted treatment.