There is no clinical cure for primary dry syndrome, but alternative and symptomatic treatments can help reduce patients’ symptoms, prevent local damage caused by long-term dry mouth and eyes, and improve the quality of life, and those who develop systemic damage should also be treated promptly. For patients with dry mouth syndrome and dry keratoconjunctivitis, artificial tears and saliva can be applied to improve dry mouth and eyes. For patients with extra-glandular manifestations such as arthritis, interstitial lung lesions, liver, kidney and neurological systemic lesions, glucocorticoids, immunosuppressants and other active treatment should be given. For those with hypokalemia due to renal impairment, intravenous or oral potassium supplementation may be administered. In the presence of malignant lymphoma, combination chemotherapy for lymphoma should be actively carried out. People suffering from primary dry syndrome should pay attention to quitting smoking and alcohol, drinking more water in daily life, and closely follow up to monitor the changes of the condition. It is recommended that patients with primary dry syndrome go to the hospital in time for treatment under the guidance of doctors.