HPV quadrivalent vaccine should be taken care of that after vaccination you should stay for 30 minutes, avoid touching water at the vaccination site, and eat less spicy and stimulating food. In addition, women during pregnancy should not receive HPV quadrivalent vaccine. Women should stay for 30 minutes after HPV quadrivalent vaccination to avoid adverse reactions such as fever and headache after vaccination. In addition, after receiving HPV quadrivalent vaccine, they should avoid letting the inoculation site come into contact with water to prevent symptoms of infection such as redness, swelling, and pain. Women should pay attention to their diet during HPV quadrivalent vaccination and eat less spicy and stimulating food, such as chili peppers, onions, garlic, etc., to avoid irritating food causing redness and swelling at the inoculation site. In addition, women during pregnancy should not receive the HPV quadrivalent vaccine to prevent the vaccine components from affecting the development of the fetus. If pregnancy is detected during HPV quadrivalent vaccination, the doctor should be informed promptly and the vaccine should be continued after delivery. Women should pay attention to their diet and post-vaccination care during HPV quadrivalent vaccination. If symptoms such as redness, swelling and pain occur after HPV quadrivalent vaccination, they should seek medical treatment promptly.