Negative aqp4 antibodies are not serious. aqp4 belongs to a type of water channel protein that is concentrated in the optic nerve and spinal cord area, and is mainly used in the clinic for the diagnosis of optic neuromyelitis optica. If the aqp4 antibody is positive, it is basically a diagnosis of optic neuromyelitis optica and needs to be treated as soon as possible. If aqp4 antibody is negative, it is not serious and usually suggests idiopathic optic neuritis, which should be treated with immunosuppressants under the guidance of a specialized doctor. If the aqp4 antibody test result is negative, the risk of recurrence is usually significantly lower than that of positive patients after the condition has improved. Although a negative aqp4 antibody test is not serious, it is still necessary to actively cooperate with professional doctors for standardized treatment. After obtaining the aqp4 antibody test report, one must adjust one’s state of mind, face up to the disease, carry out treatment early, and go to the hospital regularly for rechecks to keep abreast of the antibody changes.