Patient female, 40 years old, three months ago due to stone cholecystitis acute attack laparoscopic cholecystectomy, three months after the operation found the right side of the retroperitoneum huge mass occupying lesions, size 35x25x15cm, up to the posterior hepatic, pelvic iliac blood vessels, extrusion of the entire right side of the abdominal cavity, the intestinal tube will be moved to the left side of the abdomen, the mass is huge, extended to the left side of the spine and the mesenteric blood vessels neighboring the back of the pressure of the vena cava, the surgical risk is very great, plus the slightest accidental vascular injury will be fatal. The operation was extremely dangerous, and the slightest carelessness of vascular injury would be fatal. In addition, laparoscopic surgery had been performed, and the difficulty of re-laparoscopic surgery had been increased, and the minimally invasive surgery department had repeatedly demonstrated that there was no precedent of minimally invasive treatment in the world for similar cases, so in order to satisfy the patient’s earnest wish for minimally invasive surgery, the patient attempted to have laparoscopic reoperation for the eradication of the retroperitoneal tumor. Under the guidance of Prof. Wu Jinjiu, a famous expert in hepatobiliary surgery in China, and Prof. Jiang Bo, the president of Hunan Hepatobiliary Hospital, Prof. Yin Xinmin, the director of Provincial Laparoscopy Quality Control Center and the director of Minimally Invasive Surgery Department of Hunan Provincial People’s Hospital, performed the laparoscopic reoperation via transabdominal approach. The surgery separated the adhesion, cut the right posterior peritoneum, resected the right kidney fat capsule before the right kidney, exposed the right ureter and iliac lumbar blood vessels and nerves, lifted up the whole tumor and separated it from the vena cava, separated the mesenteric blood vessels from its left side carefully to avoid damaging the root blood vessels of the mesentery and causing necrosis of the whole small intestine, and then separated the adhesion of the tumor and the right adnexa of uterus to resect the whole tumor and then removed it through the caesarean section incision in the lower abdomen. The whole operation lasted more than seven hours, with less than 50 ml of bleeding, no blood transfusion, rapid postoperative recovery, no tumor residue and fluid accumulation on CT, and the displaced bowel was reset, and the patient was discharged from the hospital one week after the operation. The success of laparoscopic reoperation in this rare case marks a new level of minimally invasive surgical treatment in our province, and also brings good news to patients with retroperitoneal giant tumor.