Gastric antrum 0.6cm elevation with depression is considered to be inflammatory polypoid changes caused by chronic gastritis or gastric cancer, which can be treated with medication or surgery, and the corresponding treatment should be chosen according to the pathologic examination to clarify the benign and malignant nature. 1. Pharmacological treatment: if polypoid changes are caused by chronic gastritis, gastric mucosal protectants, proton pump inhibitors, bismuth, antibiotics, etc., and drugs promoting gastrointestinal motility can be used as prescribed by doctors. If it is caused by gastric cancer, medicines can be used to relieve cancer pain as prescribed by doctors, and some gastric cancers can be treated with targeted drugs. 2. Surgery: If it is chronic gastritis polyp, endoscopic surgery can be used to remove it, which usually has no complication and less possibility of recurrence after surgery. If it is gastric cancer, early surgical resection is recommended to avoid metastasis; advanced gastric cancer should decide whether to operate according to the metastatic situation of patients. The 0.6cm bulge with depression in the gastric antrum can be caused by a variety of reasons, so it is recommended to improve the relevant examinations and take appropriate treatment measures after clarifying the pathological changes. Patients should actively consult doctors and cooperate with treatment to avoid deterioration of the condition.