Director of the Pain Branch of the Tianjin Medical Association Director of the Pain Department of the First Central Hospital of Tianjin, Professor Zheng Baosen Pain Department of the First Central Hospital of Tianjin, Zheng Baosen Post-herpetic neuralgia, just as the Honorary Director of the Pain Branch of the Chinese Medical Association, Academician Han Jisheng said, post-herpetic neuralgia has 2 major characteristics, one is the wind blowing, that is, gently touching the site of herpes zoster will cause patients severe pain, many Patients are afraid of wearing clothes and touching the skin to induce severe pain, no matter what season. Secondly, when the shingles area is not touched, it suddenly appears spontaneously to produce unbearable electric shock-like pain, and the patient then has a painful expression of unbearable pain. It has been clinically proven that analgesic medication alone can relieve pain, but it is difficult to cure postherpetic neuralgia completely, so what are the results of interventional techniques to treat the disease? According to the 2013 International Pain Research Society, a panel of experts investigating the global treatment of postherpetic neuralgia with interventions suggested that the early treatment of postherpetic neuralgia is very effective, while the late treatment is very difficult. The authors were the first in China to apply paravertebral treatment techniques that can effectively control acute pain after herpes zoster, consistent with the recommended treatment proposed by the 2013 International Society for the Study of Pain Neuropathic Pain Group (NeuPSIG). Some research data confirm that sympathetic nerve blocks are ineffective in the treatment of postherpetic neuralgia. In recent years, a method using intramedullary injections of analgesics into the medullary fluid has been shown to be only partially effective. No convincing studies have been reported on the use of spinal cord electrical stimulation for postherpetic neuralgia. A recent study of pulsed radiofrequency treatment of postherpetic neuralgia showed that pain scores and analgesic doses decreased significantly after 6 months of treatment with once weekly treatment for 3 weeks, but pain relief was not complete. Why is postherpetic neuralgia so difficult to treat? The nerve cell that causes postherpetic neuralgia is located in the intervertebral foramen where the spinal nerve is pierced out of the body. The other nerve travels outward along the spinal nerve and is distributed throughout the body from the head and cervical spine to the skin of the lower extremities. None of the current domestic or foreign treatments involve the diseased spinal nerve cells within the package. Despite all the treatment methods used by ancient and modern medical practitioners to treat postherpetic neuralgia, it still cannot be eradicated. The above analysis suggests that in order to effectively relieve postherpetic neuralgia, we must work on the spinal ganglion cells. Since 2000, the authors have been exploring ways to address targeted therapeutic techniques for spinal ganglion cells that people have not been able to address in the past. After 15 years of unremitting efforts, the pain management team led by the authors has confirmed through countless animal experiments and clinical applications that the effect of transdorsal root ganglion intervention with adriamycin guided by modern imaging instruments for postherpetic neuralgia is reliable. This treatment method is similar to the Chinese acupuncture technique, except that it requires the safe and precise injection of a microscopic amount of drug under the guidance of imaging instruments to deliver the drug into the spinal nerve cells through the blood-nerve barrier. For more than 10 years, the authors have treated patients with postherpetic neuralgia from all over the country, from Guangxi, Hainan, and Yunnan in the south; Beijing, Inner Mongolia, Heilongjiang, Jilin, and Liaoning in the north; and Shandong, Jiangsu, Zhejiang, and Shanghai in the east. In 2014, the authors received another National Science and Technology Support Program project led by Prof. Chen Jun, Director of the Pain Research Institute of the Fourth Military Medical University, namely, the Demonstration of Neuropathic Pain Intervention Multi-Center Study, which is organizing more than 10 university hospitals across China to conduct clinical validation using the treatment methods studied by the authors. work. This research work will represent the cutting-edge technology of clinical pain medicine in China. Once proven, this technology will undoubtedly provide one of the most valuable results in the centuries-long search for the treatment of postherpetic neuralgia.