1.In order to monitor the toxic side effects of drugs, all immunosuppressants need to be regularly rechecked during the period of taking blood routine, urine routine, liver function, kidney function; 2.Special attention should be paid to the monitoring of white blood cells and liver function: when the blood white blood cells are less than 4000/ml or ALT/AST is more than 80u/l, the drug should be stopped and come to the hospital to avoid serious consequences or life threatening. 3.After the first visit, a half-monthly review is required, and monthly reviews can be conducted afterwards. 4.Take the hormone before 8:00 a.m. every day to reduce side effects. Do not take it more than once a day, and monitor blood sugar, lipids and blood pressure when necessary. 5.Methotrexate should be taken only once a week, and it is better to take it at night before going to bed, remember not to take it every day.