Metformin and Glimepiride both work to lower blood sugar and are used to treat type 2 diabetes. Metformin is used to lower blood glucose by increasing the uptake and utilization of glucose in peripheral tissues, has the effect of improving insulin sensitivity, and has the effect of weight loss. It is mainly used for patients with high fasting and postprandial blood glucose, especially obese type 2 diabetics, with side effects such as nausea, vomiting, and lack of appetite. Glimepiride is through the stimulation of insulin secretion, and reduce blood sugar, side effects are mainly hypoglycemic reaction, nausea, vomiting, nausea. In clinical practice, the two are often used in conjunction with each other, and the effect is very good.