A high creatine kinase isoenzyme level in children is a sign of different degrees of cardiac or skeletal muscle damage, and requires prompt and symptomatic treatment to avoid delays. Laboratory tests showing high creatine kinase isoenzyme are usually more serious, suggesting myocarditis or skeletal myositis. Children’s immunity is relatively low, and when they are infected by viruses and do not receive timely and effective treatment, it is easy to induce myocarditis or skeletal myositis, and they need to be hospitalized in time and given symptomatic treatment according to the doctor’s instructions. At the same time, it is necessary to strictly rest in bed for at least two weeks, reduce the amount of activity, and assist in regular review to clarify the level of creatine kinase isoenzymes, and clarify the recovery of cardiac muscle or skeletal muscle, so as to promote the early recovery of children. It is recommended to maintain a light and easy-to-digest diet during the treatment period to avoid the influence of adverse factors, which can help to shorten the course of the disease. If the child is not feeling well, he or she should go to the pediatric department of the hospital in a timely manner and consult a pediatrician for guidance.