Alzheimer’s disease may present with a lack of energy, which is mainly seen in patients with moderate or severe disease. Alzheimer’s patients usually show memory and calculation loss, cognitive dysfunction, behavioral abnormalities, etc. With the development of the disease, patients are also prone to some mental disorders, such as emotional apathy, anxiety, depression, etc., which will make it difficult for patients to complete the work that they used to be able to do in the past, and they will feel overwhelmed, resulting in the feeling of being drained of energy. In the later stages of Alzheimer’s disease, in addition to the gradual aggravation of the patient’s symptoms, other systemic complications such as lung infections and urinary tract infections may also occur, which may also lead to the symptoms of weakness. In conclusion, some patients with moderate or severe Alzheimer’s disease can have the symptom of lack of energy, and if this happens, active treatment is needed.