Methylcobalamin, glutamine and vitamin B12 can generally be taken together, there is no contraindication between the three, but should pay attention to the contraindications and adverse drug reactions. Methylcobalamin is used in the treatment of peripheral neuropathy, is prohibited for people who are allergic to this product, is not recommended to work with mercury and mercury compounds long-term and large amounts of people. Adverse reactions such as diarrhea, nausea, vomiting, loss of appetite, skin rash may occur after use of the drug. Glutamine is indicated for patients with neurosis, premenstrual tension syndrome and menopausal syndrome. It is contraindicated in people who are allergic to Glutathione. Adverse reactions such as stomach upset, nausea, vomiting, dry mouth, rash, and hair loss may occur after use. Vitamin B12 is used in the treatment of megaloblastic anemia, and the contraindications to the use of the drug are not clear. The adverse reactions of hypokalemia and hyperuricemia may occur after the use of the drug. The above three drugs generally do not have drug interactions, at the same time to meet the indications for the use of drugs, can be under the guidance of a physician for the simultaneous use of drugs, the specific dosage can follow the doctor’s instructions.