In clinical practice, once a patient develops a pancreatic fistula, he or she will experience significant abdominal pain, as well as abdominal distention, nausea, vomiting, and fever. This is because pancreatic fistula can cause serious abdominal infection in patients, which can lead to a series of symptoms of infection, and must pay attention to the occurrence of pancreatic fistula. Once a patient has a pancreatic fistula, adequate drainage needs to be given and anti-infective treatment needs to be intensified, preferably with broad-spectrum antibiotics for anti-infective treatment. If the patient has more pancreatic fistulas, a bacterial culture plus a drug sensitivity test must be done so that a better antibiotic can be selected for symptomatic treatment. Pancreatic fistulas can sometimes cause patients to suffer from abdominal hemorrhage, and once they occur, the prognosis is usually poor.