Vulvar leukoplakia biopsy is mainly to clarify the nature of the disease and to observe whether there is any early cancerous changes, so as to provide a basis for subsequent treatment. Malignant changes of vulvar leukoplakia are rare, but the possibility of malignant changes is not excluded, and biopsy can detect the presence of cancer as early as possible. Repeated localized ulcers, hyperplasia, nodules, etc., usually require biopsy. If it is clear that malignancy exists, surgery should be performed as soon as possible, and the prognosis is usually better through treatment. If it is clear that cancer is not present, medication can be used. If the patient has vulvar leukoplakia, it is recommended to consult a doctor in time, and under the guidance of the doctor, improve the biopsy examination, clarify the cause of the disease, and target treatment.