Oral chemotherapeutic agents and direct chemotherapy simply differ in the mode of administration, with direct chemotherapy generally referring to intravenous chemotherapy. The mode of administration is generally chosen according to the drug metabolism characteristics of chemotherapeutic drugs, dosage form, and the purpose of drug administration. 1. Intravenous drug delivery: it is the most common way of drug delivery, with the advantages of precise dosage, avoiding direct toxicity to the gastrointestinal tract and muscles, and being able to reduce the stimulation of blood vessels; the disadvantages are the inconvenience of operation, deep vein catheterization is generally required, the metabolism of the drug takes a long time to clear up and the emergence of adverse reactions often lasts for a period of time, and the side effects are larger. 2. Oral administration: the advantage is convenient to adjust, the effect is durable and smooth, the side effect is small, even if the adverse reaction is easier to control; the disadvantage is the utilization rate is low, the gastrointestinal tract has stimulation, the gastrointestinal function is not good people will affect the efficacy of the drug, severe vomiting patients should not be applied to the oral drug. In addition to oral and intravenous administration, there are also local ways of drug administration, such as intrathecal injection, intra-arterial chemotherapy, intrathecal administration, etc. For the specific choice of which way to choose, you can consult a professional doctor’s opinion.