Rheumatoid knee arthritis pain can be treated with antibiotics such as penicillin to fight infection, NSAIDs such as aspirin for anti-inflammation and analgesia, and glucocorticoids such as prednisone to relieve inflammation. Rheumatoid knee arthritis usually refers to arthritis caused by rheumatic fever, the treatment needs to be based on penicillin, erythromycin, azithromycin and other antibiotics to target streptococcal infections, to avoid recurrent episodes; and the need for pain treatment, preferred non-steroidal anti-inflammatory drugs, such as aspirin, indomethacin, but also the use of glucocorticoids, such as prednisone to relieve the inflammation. All of the above drugs should be used in accordance with medical advice. It is recommended that patients with rheumatoid knee osteoarthritis go to the Department of Rheumatology and Immunology of the hospital for a clear diagnosis and standardized treatment.