Since 98% of the body’s creatine is stored in muscle tissue, most of the urine creatine found to be elevated during a urine test is due to pathology. It is caused by damage and destruction of muscle tissue in the human body from various causes, such as crushing syndrome, burns, fractures and other traumatic injuries, as well as myotonic dystrophy, hyperthyroidism, dermatomyositis, polymyositis, leukemia and diabetes. There is also a small percentage due to physiological causes, in children during periods of rapid growth, during pregnancy, in women about two weeks after childbirth, as well as starvation and raw meat consumption. If physiological causes of elevated urinary creatine are ruled out, professional medical tests must be conducted to identify the pathological causes of elevated urinary creatine so that early treatment can be carried out to avoid serious damage to health.