Herpes in the large intestine, now as pain can occur inside the abdomen of the large intestine, especially where herpes is present, and the pain can be more limited. If the herpes affects the nerves of the intestine, there will be pain radiating from the nerves of the intestine. If food passes through the intestine where the herpes is present, it can irritate the herpes and cause pain. So the pain is not too pronounced on an empty stomach, but it is possible that two hours after eating something may induce pain in the intestines, and an abnormal watery discharge or mucous-like discharge may be seen on the stool. If herpes ruptures leading to local wound infection, it may be possible to induce enlargement of the lymph nodes in the intestine or mesentery and symptoms of abdominal pain and generalized fever.