When hemodialysis is performed, the hemodialysis flow rate of adults is generally best at 200~300ml/min, and the hemodialysis flow rate of children is best according to the principle of 3~5ml/kg-min. When hemodialysis is performed, the removal of solutes is related to relevant parameters such as blood flow rate, dialysate flow rate, dialyzer membrane area and dialyzer permeability, etc. When the blood flow rate is higher, the dialysate flow rate is faster, the area of the dialyzer membrane is larger, and the permeability of the dialyzer is higher, the removal of solutes will be more adequate, which will lead to the best effect of hemodialysis. If the blood flow is too low, it will further lead to a decrease in the adequacy of dialysis; however, too high a blood flow is more demanding on the vascular access and cardiovascular system, and too high a blood flow is damaging to the vascular endothelium. For patients who are prone to hypotension and heart failure during dialysis, blood flow should also not be too high; for patients on induced dialysis, blood flow should also not be too high, as too high may lead to increased levels of blood creatinine and urea nitrogen, and the lower the blood flow, the lower the purpose of induced dialysis is to reduce the efficiency of dialysis and increase the patient’s tolerance. Therefore, it is generally recommended that a hemodialysis flow rate of 200-300 ml/min is generally best for adults, and a hemodialysis flow rate of 3-5 ml/kg-min is best for children according to the principle of 3-5 ml/kg-min. Patients undergoing dialysis treatment are recommended to go to regular hospitals for regular treatment and choose the best hemodialysis flow rate according to the doctor’s instructions.