Cough due to mycoplasma infection in adults is often characterized by a dry cough without significant coughing up of sputum. Mycoplasma infections are characterized by the following features in addition to those mentioned above: i. Mycoplasma infections are not associated with fever or only low-grade fever. ii. Second, the blood routine is normal, only a few patients show a mild increase in white blood cell count. Mycoplasma infections are rare in the elderly aged 65 years or older. Fourth, the application of cephalosporin and penicillin and other antibiotic treatment is ineffective, need to apply levofloxacin, azithromycin and other antibiotics to give targeted treatment. Mycoplasma infection can also do mycoplasma antigen, mycoplasma antibody and mycoplasma DNA test and other related tests to assist in the diagnosis, the clinical will be combined with the patient’s condition as well as the above relevant examination to make a diagnosis, and then give the appropriate treatment.