The main side effects that occur after the use of analgesic and sedative drugs include respiratory depression, damage to the gastrointestinal mucosa, stressful gastrointestinal bleeding and drug allergy. In general, after the use of analgesic and sedative drugs, patients’ blood vessels are in a dilated state, which can lead to a decrease in their blood pressure and, in severe cases, respiratory depression. In addition, patients may develop allergic symptoms such as skin itching and shock. Therefore, during the use of analgesic and sedative drugs, patients’ respiration and blood pressure should be observed and the dosage of drugs should be adjusted in a timely manner.