Interferon injection may cause swelling and pain in the liver area, if necessary, consult the attending physician, improve liver function and liver ultrasound and other tests to assess the severity of adverse effects. Interferon is mainly indicated for chronic hepatitis B, chronic hepatitis C, chronic hepatitis D, laryngeal papilloma, hairy cell leukemia, chronic myeloid leukemia, chronic myeloid leukemia-induced thrombocytosis, multiple myeloma, renal cell carcinoma and other diseases. Common adverse reactions to interferon include pharyngitis, viral infections, bronchitis, herpes simplex, rhinitis, etc. The hepatobiliary system can cause hepatomegaly and hepatotoxicity. Therefore, interferon can cause hepatomegaly, liver injury appearing swelling and discomfort in the liver area, in addition, if the patient has viral hepatitis, may also appear pain and discomfort in the liver area. It is recommended to consult the attending doctor, combine the symptoms and signs, and improve the liver function and liver ultrasound and other tests to evaluate the condition.