Whether or not a giant baby grows up to be normal is related to the presence of combined birth complications, the presence of underlying diseases during the mother’s pregnancy, and the environment in which the baby is raised after birth. These infants are clinically known as high-risk infants because of the risk of brain damage and require early monitoring, follow-up management and, if necessary, early treatment to return the infant to normal development. Without early intervention, children may develop neuropsychiatric developmental disorders such as mental retardation, delayed language development, and cerebral palsy. However, current studies have shown that there is no significant difference in the intellectual development of uncomplicated giant children and infants of the same age. The incidence of childhood obesity increases significantly as the giant infant grows older, and the infant is at increased risk of developing metabolic syndrome. Reducing the incidence of gestational diabetes, enhancing maternal health education, modifying lifestyle, and focusing on health management in childhood can reduce the burden of disease in the offspring in the distant future and reduce the risk of metabolic syndrome in infants when they grow up.