Patients with onychomycosis are treated by cotton stuffing, which is usually inserted between the nail and the nail bed to allow the nail to cross over the higher granulation. Cotton plugging is usually used to treat milder forms of onychomycosis by sterilizing the entire nail and inserting soft cotton or cotton wool between the nail and the nail bed. Before filling, it is necessary to remove the secretion and keep the area dry, after filling to ensure that the nail can cross the higher granulation, the specific operation needs to be carried out by a professional doctor, for patients with more exudate need to change the cotton every day, and weekly review. It is recommended that patients keep their toes clean during the treatment period, avoid aggravating the condition by wearing tight shoes, and take antibiotics such as cefadroxil and metronidazole under the guidance of the doctor for more serious infections, and opt for surgical treatment if necessary.