Low β2-microglobulin usually has no special clinical significance and may be a normal physiologic manifestation of the body.
β2-microglobulin is a protein secreted by human lymphocytes, polymorphonuclear leukocytes, platelets, and other cells. β2-microglobulin can be detected in plasma, urine, and cerebrospinal fluid in normal people, but the amount is very small. Plasma β2-microglobulin is only 1.0 to 2.0 mg/L, while urine <0.3 mg/L.
β2-microglobulin is a very small molecular weight protein that can be filtered out through the glomerular filtration membrane, whereas the proximal tubules can reabsorb 99.9% of the β2-microglobulin filtered out of the glomerulus. If the amount of urinary β2-microglobulin is elevated, it suggests possible renal impairment. It is necessary to consult a doctor in time, improve relevant examinations to clarify the cause of the disease, and treat the cause of the disease.
If β2-microglobulin is found to be abnormal, patients are advised to go to regular hospitals for timely consultation, improve the examination to identify the cause of the disease, and give targeted treatment or therapy under the guidance of the doctor.