Gastroscopic anesthesia is given by intravenous application of propofol injection, which is a central sedative, mainly to put the patient in a state of complete sleep, and a moderate sleep state, without any sensation. In this case, during the gastroscopy process, the patient is not in any discomfort, can provide a relatively quiet operating environment, and for the operator, can effectively improve the examination of the esophagus, stomach, duodenum and other aspects. Especially for localized mucosal atypical hyperplasia, it can play a local magnification, together with NBI staining and other correlative examinations, which is of great help to improve the detection rate of early cancer. And gastroscopic anesthesia is also very helpful for some endoscopic treatments when provided.