Kirschner’s syndrome, i.e., congenital varicocele hypoplasia, is characterized by small and hard testes, gynecomastia, hypogonadism, and high follicular estrogen in males. The patients mostly consult the doctor for infertility or sexual dysfunction. The cause of the disease is mainly congenital chromosome mismatch, which can also be induced by drugs, environmental pollution and advanced age. Treatment is based on estrogen supplementation under the guidance of a doctor, and regular blood tests and liver and kidney function tests are required during the period of taking the medication. For patients with fertility needs, IVF can also be considered after surgical sperm retrieval. Finally, it is worth mentioning that Crohn’s syndrome is a chromosomal abnormality, so it is very necessary to do a pregnancy test before or during pregnancy for early prevention.