Uneven density of the thyroid gland is a description of thyroid ultrasound, which can be caused by inflammation of the thyroid gland, thyroid nodules, etc. Consultation with a doctor is recommended. 1. Inflammation of the thyroid gland: Hashimoto’s thyroiditis, acute suppurative thyroiditis, subacute thyroiditis and other inflammatory diseases can lead to the impairment of the immune system of the thyroid follicular cells, which in turn can cause uneven distribution of the density of the thyroid cells. 2. Thyroid nodules: benign nodules such as thyroid adenoma, simple enlargement, nodular goiter, cyst, malignant nodules such as papillary carcinoma, medullary carcinoma, undifferentiated carcinoma, etc., can cause changes in density of thyroid tissue and uneven density. If the density of thyroid gland is not uniform, one should consult a doctor in time, and the specialist should clarify the condition and then actively carry out appropriate treatment, which will help to cure the disease as soon as possible.