The combination of Cephalosporin and diuretics may cause kidney injury. In general, both cephalosporin and diuretics may cause kidney injury, so the combination of the two may cause kidney injury, but the situation is relatively rare. Cephalosporin, or cephalosporin, is a commonly used antibiotic in clinical practice. The first generation of cephalosporin has a certain degree of nephrotoxicity, can cause blood creatinine increase, urinary protein, oliguria and so on. The second generation of cephalosporin is less nephrotoxic than the first generation of cephalosporin, and the third and fourth generation of cephalosporin are basically non-nephrotoxic. Clinically used diuretics are furosemide, spironolactone, hydrochlorothiazide and so on. Diuretics cause renal injury due to factors such as affecting renal blood circulation, aggravating renal load, and causing hyperuricemia, but it is relatively rare in therapeutic doses. If patients need to apply cephalosporin and diuretics, it is recommended to use the drug under the guidance of a doctor, not blindly self-medication to avoid adverse effects.