Eczema-like carcinoma is a skin tumor that can manifest clinically as eczema-like lesions because a large, lightly stained abnormal cell called Paget cell can be seen on histopathology, so eczema-like carcinoma is often also referred to as Paget’s disease. Paget’s disease can be divided into breast Paget’s disease and extramammary Paget’s disease. Paget disease of the breast almost always involves women and occurs in the unilateral breast and areola, with an average age of onset of 55 years and rarely in the male breast. The lesions begin as scaly erythematous plaques or plaques, often with eczema, epidermal erosions, oozing or crusting, and marked infiltration, slowly expanding peripherally, which can lead to ulceration and nipple retraction. It may be associated with axillary lymph node metastases. Extramammary Paget’s disease can be cumulative in both sexes, with an average age of onset greater than that of Paget’s disease. The patient I mentioned above has extramammary Paget disease. Extramammary Paget disease occurs in the scrotum, female genitalia, perineum, and around the anus. The lesions are similar to breast Paget’s disease but are larger in size and appear as well-defined red patches or plaques with an eczema-like surface, vesicles, oozing or crusting. There is painful itching. In some patients, the lesions are called secondary extramammary Paget’s disease, because they extend from rectal adenocarcinoma to the perineum or from cervical cancer to the vulva. For middle-aged and elderly patients with eczema-like patches on unilateral breast or scrotum, vulva and perianal area, with infiltration at the base, slow and persistent course, if treatment as eczema is ineffective, eczema-like carcinoma should be suspected and pathological biopsy can confirm the diagnosis.