A slightly smaller liver with wavy altered margins and a slightly enlarged spleen are part of the imaging picture, and the most common causes for the description of the liver as well as the spleen are cirrhosis and portal hypertension. Liver injury is followed by regeneration of liver cells. Repeated injury and cell regeneration alternately lead to fibrosis of the liver, which further leads to a decrease in the size of the liver and unevenness of the edges, thus progressing to cirrhosis of the liver. As cirrhosis progresses, it leads to an increase in portal vein pressure, and localized stagnation can further lead to an enlarged spleen, which can be manifested by imaging tests. The main causes of cirrhosis include hepatitis B and alcoholic liver, etc. The occurrence of the corresponding conditions need to be combined with the clinical history and blood tests to make a comprehensive judgment, and after the diagnosis of the specific causes of the disease, standardized treatment under the guidance of the clinician.