Fetal anomalies can be checked for genetic predisposition by doing NT, Down’s syndrome screening, non-invasive DNA test, ultrasound, amniocentesis and other methods. 1. NT examination: generally can be examined at 12 to 14 weeks of pregnancy, through the ultrasound measurement of fetal nuchal translucency to initially determine whether the fetus is abnormal. 2. Down’s syndrome screening: blood is usually drawn between 16 and 20 weeks of pregnancy. 3. Non-invasive DNA test: generally requires blood sampling between 16 and 20 weeks. 4. 4D ultrasound: it is of great significance in determining whether the fetus is malformed or not, and is generally required between 22 and 26 weeks of pregnancy. 5. Amniocentesis: It is an invasive test to further confirm the diagnosis of various possible malformations found in prenatal screening. It is recommended that pregnant women follow the doctor’s instructions to carry out timely screening for fetal anomalies and routine pregnancy tests, such as the discovery of fetal anomalies when necessary to terminate the pregnancy in a timely manner, at the same time, women should be in the pre-pregnancy folic acid supplementation 3 months to prevent malformations, before and after the pregnancy should be kept away from radiation, drugs that may cause malformations, and so on.