Persistent epigastric pain and change in bowel habit may be caused by intestinal dysfunction and colitis, etc. The treatments are different according to the causes, as follows: 1. Irritable bowel syndrome: there are emotional triggers, general treatment can be carried out, such as developing regular eating habits, small meals, to ensure adequate sleep, for spicy and stimulating food to reduce intake, avoid overeating. Under the guidance of physicians, medication can also be carried out, such as trimethoprim maleate, bifidobacteria and other drugs. 2. Colitis: general treatment can be carried out, such as bed rest, to prevent overwork. Eat high nutrition, easy to digest food, low fat, low residue food. Under the guidance of physicians, medication can also be carried out, such as levofloxacin, cephalosporin and other antibacterial treatment. 3. Intestinal tumors: If it is an elderly group, and accompanied by anemia, wasting and other alarm symptoms, there is a persistent epigastric pain, change in bowel habits to be alert to the possibility of malignant tumors. It is necessary to improve the colonoscopy examination in time in order to exclude. The appearance of persistent abdominal pain, change in bowel habits, should promptly consult a doctor and identify the cause of the disease, under the guidance of the doctor to carry out targeted treatment, so as not to delay the condition.