Lumbar disc herniation is a common orthopedic disease, the main reason for its development is based on disc degeneration, especially when the degeneration of the annulus fibrosus is faster than the degeneration of the nucleus pulposus, it is easy to bulge and protrude the intervertebral discs. Percutaneous ozone nucleus pulposus ablation for the treatment of lumbar disc herniation is a new technology that has been developed in recent years in the international arena, and it has been less reported domestically in this regard. In foreign countries, ozone ablation has been recognized as the most promising means of treating lumbar disc herniation without surgery. Its mechanism of action is to use the strong oxidative properties of ozone to oxidize the nucleus pulposus and destroy the nucleus pulposus cells to achieve the purpose of making the protruding nucleus pulposus retracted and relieving the compression of the nerve root. In addition, ozone antagonizes the release of immune factors and inflammatory mediators in the inflammatory response, reduces nerve root edema and adhesions, and achieves the anti-inflammatory purpose. Ozone can inhibit unmyelinated damage receptor fibers, activate the body’s anti-damage system, and stimulate the release of enkephalins from inhibitory interneurons to exert analgesic effects. Ozone ablation is currently the safest interventional therapy, with simple operation, almost no damage and less chance of infection. After the operation, absolute bed rest for 1 week, antibiotics should be applied to prevent infection, and painkillers should be given to those with severe pain reaction. Clinical observation of ozone injection after some patients appear lower abdomen mild distension, acid around the waist the night of urinary effort, as well as nerve root harassment symptoms, generally no treatment, 24h after the basic self-relief, so that the injection of ozone treatment of herniated disc is a safe and effective method. It is generally suitable for patients with typical clinical history, symptoms and signs such as persistent or recurrent low back and leg pain, claudication, and localization signs of sensation, movement and reflexes on examination; CT, MRI or vertebral angiography in accordance with the image of disc herniation; patients with poor results of all kinds of conservative treatments; and patients with poor results of surgery and other minimally invasive interventional treatments.