Calcium deficiency can lead to bone pain, and long-term calcium deficiency may lead to bone pain. In case of calcium deficiency in middle-aged and elderly people, it will lead to osteoporosis, which will in turn lead to bone pain all over the body, mainly manifesting as pain in the lower back, presenting as wandering pain and activity pain, which can be alleviated after rest and aggravated when getting up and moving or during exercise, requiring anti-osteoporosis treatment, mainly containing two aspects of calcium supplementation and inhibition of bone destruction. In case of calcium deficiency in infants or adolescents, it may affect bone growth and lead to growing pains and cramps. Clinically, growing pains are more common, mostly seen in knee, calf or thigh pains, and reasonable calcium supplementation can relieve the pain. If patients have pain due to calcium deficiency, they should increase the intake of calcium-containing foods, such as milk and other dairy products, soy products, shrimp, fish, etc. In addition, medications are needed for patients with osteoporosis to increase bone density and reduce the risk of fracture.