If the bilirubin is mainly elevated by indirect bilirubin, it can be seen in various types of hemolytic diseases. For example, neonatal jaundice or hemolytic anemia, so we also need to do relevant auxiliary tests for hemolytic anemia, such as autohemolytic test, anti-human globulin test, blood routine, urine routine, etc., to consider blood system diseases; if the jaundice is mainly elevated by direct bilirubin, it is mostly seen in various types of obstruction inside and outside the liver, causing jaundice caused by poor bile flow, and the ratio of direct bilirubin to total bilirubin is often greater than 55% or more. In addition to routine blood tests, further investigations of γ-glutamyl transpeptidase, alkaline phosphatase, and other obstructive enzymes, as well as MRI, CT, and ultrasound if necessary, are required to observe the bile ducts inside and outside the liver. Mixed jaundice can occur in patients with hepatocellular damage. Mixed jaundice, in which the straight bile and indirect bile are all elevated, is seen in all types of liver disease, mainly chronic hepatitis, acute hepatitis, viral, drug and alcoholic, with hepatocellular damage and mixed jaundice. In this type of obstructive jaundice, surgery must be performed, such as endoscopic ERCP and stenting of the common bile duct. The principle of treatment for jaundice must be to treat the cause of the disease and treat the symptoms on the basis of the original disease.