Symptoms of advanced stage of lung cancer mainly manifest as central nervous system symptoms, bone system symptoms, extrapulmonary symptoms, cardiovascular system symptoms and so on. 1. Symptoms of central nervous system: they mainly include nausea, vomiting, headache, aphasia, fainting, hemiplegia and so on. 2. Orthopedic symptoms: the tumor may invade the pelvis, spine, ribs and other parts of the body, which may lead to bone pain and pathological fracture. 3. Extra-pulmonary symptoms: extra-pulmonary symptoms mainly manifest as bone and joint hypertrophy, male breast development, limb pain and weakness. 4. Cardiovascular symptoms: heart murmur can be heard, and non-bacterial endocarditis such as arterial embolism may occur. 5. Respiratory symptoms: cough, blood in sputum or even hemoptysis, chest tightness, shortness of breath and other respiratory symptoms may occur. Patients must pay attention to actively cooperate with doctors to receive chemotherapy, radiotherapy and other comprehensive treatment.