Growing pains are not the same as leukemia leg pain, and there is a difference between physiological and pathological. 1. Growing pains: Growing pains occur in children in the process of growth and development, the pain is symmetrical and often occurs in the lower limbs and at night. It is caused by high activity and rapid bone growth. Because they are physiologic, they generally do not require treatment. If the pain is obvious, it can be relieved by hot compresses and massages, and the diet can be strengthened with nutrition and more calcium supplements. 2. Leukemia leg pain: leukemia belongs to the malignant tumors of children’s blood system, leg pain often occurs below the knee, accompanied by sternal pressure pain, belonging to pathological pain. Clinical treatment of leukemia can be applied at the same time analgesic drugs to relieve pain. The drugs include acephate cytidine, zoerythromycin, arginine ibuprofen and so on. If leg pain occurs or leg pain is not relieved for a long time, it is recommended to consult a doctor in time, clarify the cause of the disease with the help of a doctor, and carry out targeted treatment or therapy.