Millet pimples on the skin may be caused by closed mouth acne, sweat duct tumors or milia. It is recommended that patients eliminate them through medication or physical treatments such as laser therapy or electrocautery after clarifying the specific cause of the disease under the guidance of a specialist. 1. Closed-cell acne: For patients with closed-cell acne, it can be improved by topical retinoids (alternatives include azelaic acid and salicylic acid), such as retinoic acid cream and adapalene gel to promote exfoliation and improve localized skin lesions. 2. Sweat duct tumor: Sweat duct tumor is caused by the abnormal differentiation of the ducts of the sweat glands, this disease is a benign tumor, which can be improved by high-frequency electric knife, carbon dioxide laser and other forms of phototherapy. 3. Milia: Milia can be divided into congenital and acquired, occurring in the epidermis or epithelium of the appendages, patients can be treated by laser, high-frequency electric knife. “Millet pox” like appearance of the lesions may also be related to other diseases, it is recommended that timely access to regular hospitals, in accordance with specialized medical advice for a clear diagnosis, standardized treatment.