A low albumin-to-globulin ratio is usually a low ratio of albumin to globulin in the serum, and the normal range of the ratio is 1.5-2.5. A low ratio is usually caused by a lower albumin level or a higher globulin level. 1, albumin level decreased 1, synthesis disorders: albumin is mainly synthesized by the liver, when the liver lesions such as liver failure, cirrhosis, liver cancer and other diseases, the normal function of the liver is destroyed, the synthesis function of the liver decreased, albumin will exist low; 2, less protein intake: if the long-term intake of protein less or long-term malnutrition, may make the liver synthesis of albumin sources are not enough, resulting in a lower level of albumin; 2, less protein intake: if the long-term intake of protein less or long-term malnutrition, may make the liver synthesis of albumin sources. This leads to a lower level of albumin; 3, too much loss: when there are kidney diseases or wasting diseases, such as tumors, tuberculosis, burns and other conditions, the body loses a lot of albumin, and the level of albumin will become low. Second, elevated globulin levels globulin is mainly secreted by plasma cells in the body, and its function is mainly involved in cellular immunity and humoral immunity. When the concentration of globulin is elevated, it indicates the possible existence of chronic liver disease, autoimmune diseases and hematological system diseases, such as hyperthyroidism, autoimmune hepatitis, systemic lupus erythematosus, vasculitis, dermatomyositis, multiple myeloma and macroglobulinemia. The white globule ratio is an important indicator of the human body. If abnormalities occur, it is recommended to seek medical help for appropriate treatment.