There are many causes of toothache, such as periodontitis, pulpitis, periapical periodontitis, trigeminal neuralgia, etc. Due to individual differences, there is no fastest way to stop toothache, and it is recommended to give appropriate treatment after clarifying the cause of the disease. 1. Periodontitis: common symptoms such as gum edema, bleeding, chewing tooth pain with bad breath. Amoxicillin, erythromycin and other drugs can be used to eliminate the inflammation of the gums as prescribed by the doctor, and ibuprofen, acetaminophen and other drugs can be used to relieve pain. If there is periodontitis leading to periodontal abscess, you can choose to incise and drain the pus flow. 2. Pulpitis, periapical inflammation: the typical symptoms are toothache, different degrees of pain, regardless of time, some patients will have radiating pain in the head and face, accompanied by tooth loss and loosening. If the pain is severe, ibuprofen can be used as prescribed by the doctor for temporary pain relief. Pulpitis, apical periodontitis need to be treated by root canal therapy in order to completely cure the pain. 3. Trigeminal neuralgia: manifested as a side of the trigeminal nerve distribution area pain, sudden onset or recurrent pain, pain or as a needle prick, or as electrocution, jaw, teeth, severe pain can be accompanied by the same side of the muscle twitching. Carbamazepine, phenytoin sodium, gabapentin, amitriptyline and other drugs can be used to relieve pain as prescribed by the doctor. If medication is ineffective or symptoms are severe, surgical treatment such as microvascular decompression can be used. In addition, there are many other causes of toothache, it is recommended to go to the hospital in a timely manner, after clarifying the cause of the disease, follow the doctor’s instructions for treatment, the use of drugs need to follow the doctor’s instructions.