The phenomenon of not being able to open the eyes and being very tired is commonly caused by visual fatigue, eye infections or dry eye. 1. Visual fatigue: Visual fatigue occurs because the eyes feel tired when looking at objects. The symptoms of visual fatigue are generally characterized by soreness, dryness, inability to open the eyes, and fatigue, and even a small number of patients will also have the symptom of dizziness. 2. Eye infection: eye inflammation such as conjunctivitis, may be caused by bacteria, mycoplasma, viruses and other infections, can lead to infectious inflammation of the eye, redness, swelling, congestion and other symptoms, there may also be fatigue, can not open the eyes of the situation. 3. Dry eye: most of them are related to long time looking at the cell phone and computer, or ambulation in fine work or lack of rest, due to the number of blinking is reduced, thus affecting the tear secretion as well as the stability of the tear film of the surface of the eye, which may cause dry keratitis, which manifests itself as a sense of foreign body, burning sensation, and the appearance of the eyes can not be opened, easy to fatigue, and other symptoms. Eyes can not open, very fatigue, if after rest did not get better, should go to the regular hospital ophthalmology as soon as possible, usually do not rub the eyes, keep the eyes clean.