The number of platelets below which you cannot have surgery needs to be analyzed in relation to the specific surgical site. Because platelets are the blood cells responsible for stopping bleeding in the body, a decrease in platelet count increases the likelihood of bleeding in the body and makes it easier for bleeding to occur during surgery. For example, patients with liver puncture cannot undergo liver puncture surgery if their platelet count is below 50,000/mL; patients with cesarean section cannot undergo cesarean section surgery if their platelet count is below 80,000/mL; and abdominal surgery, such as appendicitis surgery and splenectomy surgery, cannot be done if their platelet count is below 80,000/mL. For cranial surgery, due to the rich blood flow in the cranial area, the requirement for platelet count is higher, and craniotomy cannot be done when the platelet count is lower than 100,000/mL.