Hereditary liver disease examination mainly includes laboratory examination, imaging examination, liver tissue biopsy, genetic analysis and so on. 1. Laboratory examination: improve the routine examination such as blood biochemistry, blood routine, pathogenetic examination, immunological examination, copper metabolism and so on. If necessary, further investigation of blood and urine amino acids, blood fatty acids, urine organic acids, bile acids, specific enzymes and so on. 2. Imaging examination: ultrasound, CT, MRI and other examinations can indicate whether there is any abnormality in the development of the liver, vascular lesions, cirrhosis, portal hypertension, hepatic space-occupying lesions, abnormal liver deposits and so on. 3. Liver biopsy: Liver histopathology can visualize the pattern of liver injury, and electron microscopy can observe whether there are structural abnormalities of organelles, whether there are intracellular deposits and their distribution. 4. Genetic analysis: Inherited metabolic liver disease is a class of diseases caused by gene mutations, most of which are autosomal recessive, and a few of which are autosomal dominant and sex chromosome inheritance. Through the analysis and research of gene defective expression metabolites, it helps to understand the pathogenesis of inherited metabolic liver disease and provides a reliable theoretical basis for gene therapy. Hereditary liver disease should be actively consulted to avoid delay.