High urinary micro-protein and urinary protein with normal urinary creatinine generally indicates an early manifestation of impaired glomerular function, which is commonly seen in diabetic nephropathy, hypertensive nephropathy, and so on. In addition, physiological conditions such as strenuous exercise, eating a large amount of high protein food can also lead to abnormalities in the above indicators. High urinary micro-protein and urinary protein appear because of the fracture of glomerular capillary wall or barrier change, so that the protein leakage exceeds the tubular reabsorption, which is an early manifestation of impaired renal function. Common causes such as diabetic nephropathy, hypertensive nephropathy, glomerulonephritis, etc. Oral dagliflozin, valsartan, prednisone acetate and other medications can be taken under the guidance of physicians. In addition, physiological conditions such as eating a lot of high-protein food, strenuous exercise, staying up all night, etc., can also lead to high urinary micro-protein and urinary protein, at this time, we need to pay attention to rest, light diet, and regular review. Patients with high urinary micro-protein and urinary protein and normal urinary creatinine are advised to go to a regular hospital for diagnosis and treatment after evaluation by a doctor.